Anti-Human C5 Recombinant Antibody (TAB-453CQ)
CAT#: TAB-453CQ
Recombinant monoclonal antibody to C5. This antibody is a human monoclonal antibody that binds specifically to C5, blocking its cleavage into C5a and C5b.
Gene Expression
Tested Data
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
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SDS-PAGE
Figure 1 Anti-Human C5 Recombinant Antibody (TAB-453CQ) in SDS-PAGE
SDS-PAGE analysis of TAB-453CQ in non-reduced (right) and reduced (left) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result of different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively.
SEC-HPLC
Figure 2 Anti-Human C5 Recombinant Antibody (TAB-453CQ) in SEC-HPLC
The purity of TAB-453CQ was greater than 95% as determined by HPLC.
ELISA
Figure 3 Anti-Human C5 Recombinant Antibody (TAB-453CQ) in ELISA
Sandwich ELISA analysis of TAB-453CQ was performed by coating with TAB-453CQ and Recombinant Human C5 (his tag).
The secondary antibody: HRP-Anti-His tag
WB
Figure 4 Anti-Human C5 Recombinant Antibody (TAB-453CQ) in WB
Western blot analysis of TAB-453CQ was performed by loading Recombinant Human C5 (His Tag).
TAB-453CQ incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-Human IgG (H+L)
Lane1: Reducing antigen (0.1 μg)
Lane2: Reducing antigen (0.3 μg)
Lane3: Reducing antigen (0.6 μg)
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1, λ2
- Specificity
- Human C5
- Species Reactivity
- Human
- Applications
- Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry; Functional Studies
- Conjugate
- Unconjugated
- Related Disease
- Choroiditis
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
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Highly specific medication
We've seen a significant reduction in adverse effects with Tesidolumab compared to older treatments. It's a highly specific medication, which minimizes off-target issues.
Impressive specificity and potency
The specificity and potency of Tesidolumab in targeting C5 are impressive. It represents a major leap forward in our ability to manage complement-mediated diseases effectively.
Manageable side effect
In our trials, Tesidolumab consistently provided therapeutic benefits with a manageable side effect profile. Its role in complement inhibition cannot be overstated.
Ba****a19.Oct,24
Excellent for ELISA
Nice ELISA data of the anti-C5 antibody to human C5 protein, aa 19-1676.
Q&As
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What is the precise mode of action of the recombinant human C5 antibody?
A: The complement system's C5 component is the specific target of tesidolumab, which inhibits its cleavage into C5a and C5b to stop the membrane attack complex (MAC) from forming. This mechanism aids in the reduction of complement-mediated disease-related inflammation and cell lysis.
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What distinguishes Tesidolumab from other anti-C5 antibodies available on the market?
A: Tesidolumab is superior to other anti-C5 antibodies in terms of its specificity and binding affinity for C5. This enhancement makes it more therapeutically effective and reduces off-target interactions, providing a more individualized therapy choice for illnesses associated with complement activation.
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In what time frame may patients anticipate seeing outcomes from Tesidolumab?
A: Some patients may notice symptom improvement within a few weeks after starting therapy, although the entire therapeutic benefit could take many months. Response times may vary depending on the individual and the illness being treated.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-453CQ, RRID: AB_3111952)
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Biosimilar Overview
Please refer to Tesidolumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tesidolumab.
Related Diseases
Systemic Lupus Erythematosus
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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